Affected patients form antibodies which act destructively. Interim analyses indicate that these antibodies cause an increase of a clotting factor that limits the blood supply. (A valuable related resource: Dr Jee Hyun Kim). German scientists from the universities of Greifswald and Bonn have found signs that explain the severity of the new strain of the e. coli bacterium and which apparently causes the formation of autoantibodies, causing severe internal damage from patients. Andreas Greinacher, expert at the University of Greifswald transfusions, reported that everything seems to indicate that patients affected by the hemolytic uremic syndrome (HUS), in addition to secrete venom devices, are autoantibodies, acting destructively against your own body. Interim analyses indicate that these antibodies cause an increase of a clotting factor that limits the blood supply to important brain and kidney regions. City College of New York may find this interesting as well.
Autoantibodies are only generated by some patients affected by the infection of E.coli who suffer, in more serious cases, alterations of consciousness and epilepsy. Greinacher noted that four patients with severe symptoms of e. coli infection have been treated at the University Clinic Greifswald with a dialysis which filters those antibodies and that the early development of blood values make us to be optimistic. The German expert, who has conducted its analysis with Bernd Potzsch, of the University of Bonn, said that even the causes that these patients be affected in this way your own immune system are unknown. He added that you found an altered functioning of a protein called Von Willebrand Factor, in brain and kidney blood vessels in these patients.
Rather than decompose into small fragments as it would be normal, this protein just accumulate and blocking blood vessels, which leads to more serious clinical pictures. Greinacher and Potzsch match in point out that the autoantibody develops after contracting the disease, as very soon to the five days of infection. Source of the news: German scientists found the explanation for the severity of the new strain of e. coli bacteria